That was certainly the case in the 2006 episode 'Cartoon Wars,' based on the violent aftermath of the illustrations of Muhammad published in the Danish newspaper Jyllands-Posten.
There are no subjects, no public figures, no cows so sacred that creators Trey Parker and Matt Stone won't lampoon them, and it seems as though they take pleasure in satirizing subjects for no other reason than that other people don't dare go near them. From episode one, South Park has staked its reputation on being the show that goes there, consistently and thoroughly.